The effect of gestataional hypertension on the ultrastructural structure of the placenta

The objective: to study pathological changes and compensatory-adaptive reactions in the structural ultrastructural components of placental barrier pregnant women with gestational arterial hypertension, who received magnesium preparations. Materials methods. 100 patients hypertension were examined. presence deficiency these was determined by results our questionnaires.Pathomorphological electronic microscopic examination 32 placentas carried out. 12 them from proposed management pregnancy, which included drugs (I group), 11 – risk preeclampsia, observed use standard approaches pregnancy for preeclampsia (II group). Control group pathomorphological 9 healthy women.Results. Placental have features, is manifested mosaic change form uneven circulatory disorders hemorrhages stasis (at level) fetal microvessels villi, reducing functional area (rapprochement villi), stromal sclerosis foci immaturity, increase calcium salts (mineral dystrophy) on background compensatory reactions. Electronic I revealed an placenta thinning barrier, activation cytotrophoblast cells number syncytiocapillary membranes terminal villi syncytiotrophoblast organic activation, ribosomes, appearance orthodox configuration mitochondria, increasing capillary syncytia, sludge phenomena microvessels, leads possibility nutrient transfer mother fetus, etc.Conclusions. therapy, involves magnesium, diosmin others substances, a significant decrease frequency detection increased can be considered result positive impact therapy elements preeclampsia.